Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. clozapine and doxepin both increase sedation. Modify Therapy/Monitor Closely. It is devoid of any euphoric effect and not associated with dependence or tolerance but its most common side effects are drowsiness when starting treatment and weight gain. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. 2012;7(6):e36889. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor.doxepin and arformoterol both increase QTc interval. doxepin and ceritinib both increase QTc interval. ziprasidone and doxepin both increase sedation. Monitor Closely (1)diamorphine and doxepin both increase sedation. butalbital, doxepin. Effect of interaction is not clear, use caution. Use Caution/Monitor. 2015 Feb;23(1):1-21. doi: 10.1037/a0038550. Use Caution/Monitor. Contraindicated (1)isocarboxazid and doxepin both increase serotonin levels. Monitor Closely (1)dipipanone and doxepin both increase sedation. Monitor Closely (1)doxepin and cocaine topical both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Avoid or Use Alternate Drug. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. Severe CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. If not feasible, avoid use of abametapir. Potential for increased TCA adverse effects. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Other (see comment). Other (see comment). Some side effects may go away after a time, while others may lead you and your doctor to try a different medication. Use Caution/Monitor. Modify Therapy/Monitor Closely. physostigmine increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. doxepin and amiodarone both increase QTc interval. Monitor Closely (1)rolapitant will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Risk of arrhythmias or hypotension. Use Caution/Monitor. itraconazole and doxepin both increase QTc interval. Minor/Significance Unknown. When oxymetazoline is combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs. Multiple mechanisms involved. Minor (1)doxepin increases effects of tolazamide by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. Effect of interaction is not clear, use caution. doxepin, prochlorperazine. doxepin and L-tryptophan both increase serotonin levels. Minor (1)doxepin increases effects of vasopressin by pharmacodynamic synergism. Use Caution/Monitor. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine subdermal implant and doxepin both increase QTc interval. Use Caution/Monitor. doxepin and octreotide (Antidote) both increase QTc interval. sufentanil and doxepin both increase sedation. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Other (see comment). This document does not contain all possible drug interactions. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. This is sometimes called discontinuation syndrome. Avoid or Use Alternate Drug. Mechanism: unspecified interaction mechanism. Monitor Closely (1)doxepin and gemifloxacin both increase QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Sedatives are not technically considered antidepressants. lemborexant, doxepin. Contraindicated (1)lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Which Insomnia Drugs Are More Effective and Have Fewer Side Effects? MeSH Comment: Risk of neurotoxicity in geriatric pts. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended. Use Caution/Monitor. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Adding plans allows you to compare formulary status to other drugs in the same class. Use Caution/Monitor. Comment: Risk of neurotoxicity in geriatric pts. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Risk of arrhythmias or hypotension. atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin and dihydroergotamine intranasal both increase serotonin levels. Either increases effects of the other by pharmacodynamic synergism. Urinary retention (trouble urinating), severeShould not be used in patients with these conditions. official website and that any information you provide is encrypted Use Caution/Monitor.Serious - Use Alternative (1)doxepin, salmeterol. Effect of interaction is not clear, use caution. other information we have about you. buprenorphine transdermal and doxepin both increase QTc interval. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Side effect. pentazocine and doxepin both increase sedation. Monitor Closely (1)clonazepam and doxepin both increase sedation. Minor/Significance Unknown. Both agents increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, albuterol. chlorpromazine and doxepin both increase sedation. Minor/Significance Unknown. Avoid or Use Alternate Drug. Additive anticholinergic effects. stiripentol, doxepin. Use Caution/Monitor. Contraindicated (1)doxepin and disopyramide both increase QTc interval. Use Caution/Monitor.doxepin and sevoflurane both increase QTc interval. Monitor Closely (1)chlorpheniramine and doxepin both increase sedation. Avoid or Use Alternate Drug. Wellbutrin XL Interactions. Avoid or Use Alternate Drug. Most Monitor Closely (1)sumatriptan intranasal and doxepin both increase serotonin levels. Profound sedation, respiratory depression, coma, and death may result if coadministered. Avoid or Use Alternate Drug. doxepin: Sinequan, Zonalon, Silenor: . Properly discard this product when it is expired or no longer needed. However, interactions are not common. Serious - Use Alternative (1)doxepin and osimertinib both increase QTc interval. Serious - Use Alternative (1)tedizolid, doxepin. Avoid or Use Alternate Drug. Potential cannabis interaction risk: High. Avoid or Use Alternate Drug. A list of the serotonergic psychiatric medications that can interact with linezolid can be found . duloxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and maprotiline both increase QTc interval. Either increases levels of the other by decreasing metabolism. and transmitted securely. doxepin and disopyramide both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. J Clin Psychiatry. Valerian: A safe and effective herbal sleep aid? Bethesda, MD 20894, Web Policies Modify Therapy/Monitor Closely.Minor (1)lithium, doxepin. doxepin, oliceridine. The usual dosage range is 75 to 150 mg per day. Use Caution/Monitor. Accessed Aug. 13, 2019. Avoid or Use Alternate Drug. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. Portions of this document last updated: Feb. 01, 2023. Use Caution/Monitor. Monitor Closely (1)doxepin and dasatinib both increase QTc interval. Estrogens may inhibit hepatic metabolism of tricyclic antidepressants. Minor/Significance Unknown. Comment: Potential for increased risk of hypotension with concurrent use. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and cyclobenzaprine both increase serotonin levels. Monitor Closely (2)cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of doxepin by decreasing metabolism. doxepin and vardenafil both increase QTc interval. Additive anticholinergic effects. Monitor Closely (2)doxepin and olanzapine both increase QTc interval. Either increases effects of the other by sedation. phenelzine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.Minor (1)duloxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin and shepherd's purse both increase sedation. doxepin and levalbuterol both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Antidepressants: Which cause the fewest sexual side effects? Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)dexmedetomidine and doxepin both increase sedation. Minor/Significance Unknown. Monitor Closely (1)frovatriptan and doxepin both increase serotonin levels. Contraindicated. Share cases and questions with Physicians on Medscape consult. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. Minor/Significance Unknown. Avoid or Use Alternate Drug. Other (see comment). hydrocodone, doxepin. Use Caution/Monitor.doxepin and aripiprazole both increase QTc interval. benzhydrocodone/acetaminophen, doxepin. doxepin and dihydroergotamine both increase serotonin levels. Effect of interaction is not clear, use caution. doxepin and melatonin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, metaproterenol. This medication is used to relieve itching from certain skin conditions (such as atopic dermatitis, eczema, neurodermatitis). Avoid or Use Alternate Drug. rivastigmine increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)papaveretum and doxepin both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. butabarbital, doxepin. doxepin increases levels of glycopyrrolate by unknown mechanism. Avoid or Use Alternate Drug.Minor (2)doxepin, chlorpromazine. Other (see comment). Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Use Caution/Monitor.desflurane and doxepin both increase QTc interval. Use Caution/Monitor. methylene blue and doxepin both increase serotonin levels. Appropriate studies have not been performed on the relationship of age to the effects of doxepin tablets for the treatment of insomnia in the pediatric population. Monitor Closely (2)doxepin and pentazocine both increase serotonin levels. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. fluoxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration. Minor/Significance Unknown. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. Use Caution/Monitor.clomipramine and doxepin both increase sedation. Use Caution/Monitor.doxepin and tapentadol both increase serotonin levels. amitriptyline and doxepin both increase QTc interval. panax ginseng increases effects of doxepin by pharmacodynamic synergism. Salt craving: A symptom of Addison's disease? Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. aripiprazole and doxepin both increase sedation. Monitor Closely (1)doxepin, remifentanil. doxepin increases and levalbuterol decreases sedation. Use Caution/Monitor. 136 are major, 503 are moderate, and 25 are minor. Avoid or Use Alternate Drug. Monitor Closely (1)opium tincture and doxepin both increase sedation. Monitor Closely (1)doxepin and levofloxacin both increase QTc interval. Either increases levels of the other by pharmacodynamic synergism. 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